Clinical Health Updates

Methylprednisolone improves outcomes in ARDS

Clinical Question:
Does prolonged methylprednisolone administered to patients with ARDS reduce lung injury and improve patient outcomes?

Bottom Line:
Methylprednisolone initiated early in the course of acute respiratory distress syndrome (ARDS) reduces the duration of mechanical ventilation and mortality in the intensive care unit (ICU).

Meduri GU, Golden E, Freire AX, et al. Methylprednisolone infusion in early severe ARDS: results of a randomized trial. Chest 2007;131:954-963.

Study Design:
Randomized controlled trial (double-blinded)

The authors determined the effects of low-dose prolonged methylprednisolone infusion on lung function in patients with early severe Acute Respiratory Distress Syndrome (ARDS). Randomized, double-blind, placebo-controlled trial was done. They did at ICUs of five hospitals in Memphis. Ninety-one patients with severe early ARDS (