Clinical Health Updates

Alfuzosin (10 mg) does not affect blood pressure in young healthy men

Clinical Question:
Does Alfuzosin 10mg safe in a normotensive BPH, distal ureteral stones and prostatitis patients?

Bottom Line:
Study shows that alfuzosin 10mg is well tolerated by young healthy subjects and may therefore be safely administered to young normotensive patients affected by distal ureteral stones and prostatitis.

Reference:
Alfuzosin (10 mg) does not affect blood pressure in young healthy men. Mondaini N, Giubilei G, Ungar A, Gontero P, Cai T, Gavazzi A, Bartoletti R, Geppetti P, Carini M. Eur Urol. 2006 Dec;50(6):1292-6; discussion 1297-8

Study Design:
Randomized Controlled Trial (Double Blind)

Synopsis:
Alfuzosin 10mg is a uroselective alpha(1)-adrenoceptor antagonist used to treat lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Recent studies have suggested the potential efficacy of alfuzosin in the treatment of distal ureteral stones and prostatitis syndrome, two conditions frequently encountered in young patients. The authors evaluated the effect of 10mg alfuzosin on blood pressure (BP) and heart rate (HR) in young healthy volunteers. They did a randomized, double-blind, placebo-controlled, crossover study, the effect of alfuzosin 10mg on BP and HR was evaluated in 14 male volunteers (mean age: 28 yr; range: 24-30). BP<135/85>10%) was recorded during each treatment.